It is reported that Zhivotovsky's
effective mutation rate
[1]
has the effect of increasing the TMRCA of a lineage, as computed by
the use of Microsattelite Genetic
Distances[2],
by a factor of 3-4 fold relative to TMRCAs computed via mutation
rates observed in pedigree and family studies
[3].
By utilizing my TMRCA calculating program,
I want to explore,
- What effect does different marker combinations have on this multiplier ?
- What effect does marker size have on this multiplier ?
- Is there a variation in this multiplier for different data-sets?
First, to ensure that my program correctly calculates the TMRCA when the
Zhivotovsky mutation rate of 0.00069 is applied to all the markers
in my database consistently (versus only the marker specific Pedigree
mutation rates I have thus far been utilizing), I attempted
to replicate the TMRCA computations of the following publication;
The emergence of Y-chromosome haplogroup J1e among Arabic-speaking populations Chiaroni et al. (2009)
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